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Rabbit Anti-GSTM4 Polyclonal Antibody

Cat NoBIOS-1072P
Conjugate
Type多克隆抗体
SourceRabbit
Size1mg
ApplicationWB
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in 0.01 M PBS; pH 7.4.
StorageStore at -20 degree for long term.
SynonymsGSTM4;GSTM4-4;GTM4
PurificationAffinity purification
MolecularWeight26-34KDa
Description
BackgroundCytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present; eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha; kappa; mu; omega; pi; sigma; theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds; including carcinogens; therapeutic drugs; environmental toxins and products of oxidative stress; by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substratebinding domains; as well as in tissue expression patterns; to accommodate an increasing number of foreign compounds. Multiple transcript variants; each encoding a distinct protein isoform; have been identified.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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