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重组蛋白

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Recombinant Human GDF15 protein (aa 197-308), His

Cat NoBIOMY104-A
Conjugate
Type其他重组蛋白
SourceYeast
TagHis
Size100 ug
Application
FormatLyophilized
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in sterile 50mM HAc, pH 2.9.
SpeciesHuman
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
Synonymsgrowth differentiation factor 15;GDF-15;MIC-1;MIC1;NAG-1;PDF;PLAB;PTGFB
Purification> 90 % as determined by SDS-PAGE
MolecularWeight18.2 kDa
Description
BackgroundGrowth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15 / GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 / GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15 / GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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