Recombinant Rabbit Anti-PHD2 Monoclonal Antibody, clone BT3402
Cat No | BQSB-1458 |
Conjugate | |
Type | 重組兔單抗 |
Clone | BT3402 |
Source | Rabbit |
Tag | N/A |
Size | 1 mg |
Application | WB; IP |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS. |
Storage | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
Synonyms | 脯氨酸羥化酶2;EGLN1;C1orf12;ECYT3;HIFPH2;HPH2;PHD2;SM-20;SM20;ZMYND6 |
Purification | |
MolecularWeight | |
Description | |
Background | Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. |
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC; Biotin; Alexa Fluor; Rhodamine B; Cy; Co-Au.