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Recombinant Rabbit Anti-GAB1 Monoclonal Antibody, clone BT2422

Cat NoBQSB-471
Conjugate
Type重组兔单抗
CloneBT2422
SourceRabbit
TagN/A
Size1 mg
ApplicationWB; IHC-P; IHC-F; ICC/IF; IF
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS.
StorageShipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Synonyms接头蛋白Gab 1;ACE-2;ACE 2;Angiotensin converting enzyme 2;ACE related carboxypeptidase;ACEH;Angiotensin converting enzyme homolog;Angiotensin converting enzyme like protein;Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2;Angiotensin I converting enzyme 2;DKFZP434A014;EC 3.4.17;angiotensin-converting enzyme 2 precursor;ACE2_HUMAN
Purification
MolecularWeight
Description
BackgroundGab1 is a 115 kDa multiple docking protein that plays an essential role in cellular growth, transformation and apoptosis. Gab1 can be phosphorylated by multiple receptor tyrosine kinase (RTKs), including: insulin receptor (IR), platelet derived growth factor receptor beta] (PDGFRbeta]), hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c Met), and epidermal growth factor receptor (EGF), as well as in response to cell cell adhesion. Gab1 is tyrosine phosphorylated on at least 16 sites, some of which serve as binding sites for phosphoatidylinositol 3 kinase (PI3K), Grb2, PLC gamma 1, Nck, and SHP2. Phosphorylation of Gab1 on tyrosines 627 and 659 is critical for its binding to SHP2, and for activation of the ERK/MAPK pathway in response to EGF.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC; Biotin; Alexa Fluor; Rhodamine B; Cy; Co-Au.
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