Cat No | BXXG-001K |
Conjugate | |
Type | 試劑盒 |
Size | 96T |
Application | Immunology |
Format | Liquid |
Storage | Store at -20℃, 12 months. |
Synonyms | 上皮細(xì)胞粘附分子;Epithelial Cell Adhesion Molecule;Tumor-Associated Calcium Signal Transducer 1;Major Gastrointestinal Tumor-Associated Protein GA733-2;Cell Surface Glycoprotein Trop-1;Epithelial Glycoprotein 314;TROP1;KSA;Membrane Component;Chromosome 4 |
Purification | |
MolecularWeight | |
Description | |
Background | EpCAM is also known as CO171A, EGP, EGP40,GA7332, KSA, M4S, MIC18, MK1, TROP1, hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer. |
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.