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抗體產(chǎn)品
- 一抗
  - --|--|流式抗體
  - --|--|單克隆抗體
  - --|--|重組兔單抗
  - --|--|多克隆抗體
  - --|--|小分子抗原抗體
  - --|--|抗體對(duì)
  - --|--|標(biāo)簽抗體
  - --|--|修飾性抗體
  - --|--|其他抗體
- 二抗
- 試劑盒
  - --|--|標(biāo)記試劑盒
  - --|--|其他試劑盒
  - --|--|ELISA試劑盒
  - --|--|標(biāo)記染料
蛋白產(chǎn)品
生物材料
- 金屬納米材料
  - --|--|金納米球
  - --|--|金納米棒
  - --|--|銀納米球
  - --|--|金納米海膽
  - --|--|碳納米顆粒
  - --|--|特殊納米顆粒
- 熒光微球
  - --|--|紅色熒光微球
  - --|--|橙色熒光微球
  - --|--|綠色熒光微球
  - --|--|藍(lán)色熒光微球
  - --|--|AIE熒光微球
  - --|--|其他熒光微球
- 磁性微球
  - --|--|PS磁性微球
  - --|--|SiO2磁性微球
  - --|--|Fe3O4磁性微球
  - --|--|功能化磁性微球
  - --|--|Magnetic Particles Conjugates
  - --|--|磁性微球試劑盒
  - --|--|其他磁性微球
- 單分散微球
  - --|--|PS微球/聚苯乙烯-100%純度
  - --|--|Silica微球/ 二氧化硅-100%純度
  - --|--|PMMA微球/聚甲基丙烯酸甲酯-100%純度
  - --|--|PET微球/聚對(duì)苯二甲酸乙二醇酯-模版法
  - --|--|PVA微球/聚乙烯醇-模版法
  - --|--|PVC微球/聚氯乙烯-100%純度/模版法
  - --|--|DVB微球/二乙烯基苯
  - --|--|PP微球/聚丙烯-模版法
  - --|--|PE微球/聚乙烯-模版法
  - --|--|GMA微球/甲基丙烯酸環(huán)氧丙脂-100%純度
  - --|--|PLA微球/聚乳酸-100%純度
  - --|--|PLGA微球/聚乙丙交酯-100%純度
  - --|--|PLLA微球/聚左旋乳酸-100%純度
  - --|--|PDLA微球/聚右旋乳酸-100%純度
  - --|--|PCL微球/聚己內(nèi)酯-100%純度
  - --|--|PTFE微球/聚四氟乙烯-100%純度
  - --|--|PBS微球聚丁二酸丁二醇酯-100%純度
  - --|--|Polydopamine微球聚多巴胺-100%純度
  - --|--|各向異性janus粒子
  - --|--|Sodium Alginate微球/海藻酸鈉
  - --|--|Agarose微球/瓊脂糖
  - --|--|Polymethylsilsesquioxane微球/聚甲基倍半硅氧烷
  - --|--|PBAT微球/聚己二酸-對(duì)苯二甲酸丁二醇酯
- 染色微球
  - --|--|黃色染色微球
  - --|--|黑色染色微球
  - --|--|紅色染色微球
  - --|--|綠色染色微球
  - --|--|紫色染色微球
  - --|--|藍(lán)色染色微球
- 其他材料
  - --|--|上轉(zhuǎn)換納米顆粒
  - --|--|量子點(diǎn)
  - --|--|色譜填料
  - --|--|纖維素微球
  - --|--|介孔材料
熱銷(xiāo)產(chǎn)品
- 猴痘相關(guān)產(chǎn)品
- 新冠相關(guān)產(chǎn)品
- 外泌體相關(guān)產(chǎn)品
- 常用試劑
  - --|--|轉(zhuǎn)染試劑
  - --|--|ELISA-FCM試劑
  - --|--|WB試劑
  - --|--|IHC-ICC-IF試劑
  - --|--|載體材料

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Recombinant Human BMPR2 Protein, His

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Documentation
Citations

Cat No	BIOP3460
Conjugate
Type	細(xì)胞因子
Source	HEK293
Tag	His
Size	20 ug
Application	Immunogen
Format	Lyophilized
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS, pH 7.4.
Species	Human
Storage	Store at –20 degree. Avoid repeated freeze/thaw cycles.
Synonyms	BMPR-II;BMPR3;BMR2;BRK-3;POVD1;PPH1;T-ALK
Purification	> 95% by SDS-PAGE.
MolecularWeight
Description
Background	The bone morphogenetic protein type II receptor (BMPR-II, or BMPR2), a receptor for the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) superfamily. Reduced expression or function of BMPR2 signaling leads to exaggerated TGF-beta signaling and altered cellular responses to TGF-beta. In endothelial cells, BMPR2 mutation increases the susceptibility of cells to apoptosis. BMPR2 transduces BMP signals by forming heteromeric complexes with and phosphorylating BMP type I receptors. The intracellular domain of BMPR2 is both necessary and sufficient for receptor complex interaction. It had been identified that BMPR2 plays a key role in cell growth. Its mutations lead to hereditary pulmonary hypertension, and knockout of Bmpr-II results in early embryonic lethality. The C-terminal tail of BMPR2 provides binding sites for a number of regulatory proteins that may initiate Smad-independent signalling. BMPR2 mutations were predicted to alter the BMP and TGF-b1/SMAD signalling pathways, resulting in proliferation rather than apoptosis of vascular cells, and greatly increase the risk of developing severe pulmonary arterial hypertension. BMPR2 gene result in familial Primary pulmonary hypertension (PPH) transmitted as an autosomal dominant trait, albeit with low penetrance. Heterozygous germline mutations of BMPR2 gene have been identified in patients with familial and sporadic PPH, indicating that BMPR2 may contribute to the maintenance of normal pulmonary vascular structure and function. Tctex-1, a light chain of the motor complex dynein, interacts with the cytoplasmic domain of BMPR2 and demonstrate that Tctex-1 is phosphorylated by BMPR-II, a function disrupted by PPH disease causing mutations within exon 12. BMPR2 and Tctex-1 co-localize to endothelium and smooth muscle within the media of pulmonary arterioles, key sites of vascular remodelling in PPH.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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Recombinant Human BMPR2 Protein, His