Recombinant Human IL-21 Protion
Cat No | BIOS-2016A |
Conjugate | |
Type | 重組蛋白 |
Source | Human |
Size | 20 ug; 100ug; 1 mg |
Application | Immunology |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in 0.01 M PBS; pH 7.4. |
Storage | Store at -20 degree for long term. |
Synonyms | CVID11;IL-21;Interleukin 21;白細(xì)胞介素21 |
Purification | > 95% by SDS-PAGE |
MolecularWeight | 15.6 kDa |
Description | Human IL21 isoform 1 (Q9HBE4-1) (Gln30-Ser162) in Escherichia coli. |
Background | IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as a therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation). |
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